Monday, January 23, 2023

Bladder Medication Myrbetriq Side Effects

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Side Effects In Older People

Overview of Myrbetriq a Prescription Medication Used to Treat Overactive Bladder

In clinical studies, side effects of Myrbetriq reported in adults ages 65 years and older were similar to those seen in younger people.

Certain other drugs used for overactive bladder may cause troublesome side effects in older people. These drugs are called antimuscarinics . In particular, these drugs may increase the risk of dementia in older people.

Myrbetriq isnt an antimuscarinic drug. Its not associated with this side effect. And its not known to cause more side effects in older people than in younger people.

Using Myrbetriq For Neurogenic Detrusor Overactivity

The FDA has approved Myrbetriq to treat neurogenic detrusor overactivity in children ages 3 years and older.

NDO is a type of overactive bladder. Its often caused by a nerve problem, which can happen with conditions such as multiple sclerosis and stroke. Symptoms of NDO overlap with those of overactive bladder and include urinary urgency, frequency, and incontinence.

Why Is This Medication Prescribed

Mirabegron is used alone or in combination with solifenacin to treat overactive bladder in adults. It is also used to treat neurogenic detrusor overactivity in children 3 years of age and older. Mirabegron is in a class of medications called beta-3 adrenergic agonists. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination.

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Ethics Approval And Consent To Participate

The study protocol was reviewed by an Independent Ethics Committee/Institutional Review Board for the study sites. Approval for the study protocol was obtained from the relevant competent authority prior to study initiation. Institutional Review Board/Independent Ethics Committee-approved written informed consent was obtained from all participants or their legally authorized representative prior to any study-related procedures.

What To Ask Your Doctor

Myrbetriq (Mirabegron): Uses, Dosage, Side Effects, Interactions, Warning

If you have overactive bladder, your condition may benefit from treatment with Myrbetriq.

Ask your doctor about the risks and benefits of taking Myrbetriq for your condition. Here are a few questions you may want to ask:

  • What should I expect when starting treatment with Myrbetriq?
  • Will I need lab work while taking Myrbetriq?
  • Is Myrbetriq safe to take with my other medications?

You can also learn more about treatment options for overactive bladder by checking out these articles:

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Watch For Signs Of An Allergic Reaction

One of Myrbetriqs most severe side effects is angioedema, an allergic reaction that causes swelling of the face, mouth, and throat. Angioedema could be life-threatening if the airways swell shut. When taking Myrbetriq, get emergency medical attention if you have symptoms of an allergic reaction such as hives, rash, itching, chest tightness, trouble breathing, blistering, or swelling.

Does Myrbetriq Cause Side Effects

Myrbetriq is a beta-3 adrenergic agonist used to treat overactive bladder with symptoms of urgency , frequency , and leakage in adults.

Common side effects of Myrbetriq include

Less commonly, some patients have problems emptying their bladder while taking Myrbetriq.

Serious side effects of Myrbetriq include

Drug interactions of Myrbetriq include medications that are metabolized or broken down by the CYP2D6 enzymes, because it can result in an increase in their blood levels. Taking Myrbetriq with digoxin causes an increase in digoxin blood levels. In clinical studies when Myrbetriq was administered with warfarin, blood levels of warfarin were increased.

Use of Myrbetriq during pregnancy has not been adequately evaluated. Due to the lack of conclusive safety data, Myrbetriq should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

It is unknown if Myrbetriq is excreted in human breast milk. As many drugs are excreted into human milk and have the potential of causing harm to the nursing infant, Myrbetriq should only be used during breastfeeding if it is clearly needed.

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Myrbetriq And High Blood Pressure

Myrbetriq can raise blood pressure in both adults and children, affecting anywhere from 7.5% to 24% of people taking Myrbetriq. In most cases, this rise in blood pressure may be minor. In clinical studies, the average rise in blood pressure was 4 mm/Hg systolic and 1.6 mm/Hg diastolic. Even a slight rise in blood pressure may be a problem in people diagnosed with hypertension. Although Myrbetriq increases blood pressure, most studies have found it to have no effect on eye pressure, so it is generally considered safe for patients with glaucoma.

What If I Miss A Dose

Are Bladder Medications SAFE?! | OVERACTIVE BLADDER Medications

Try to take your dose of Myrbetriq at around the same time each day. This can help you remember it.

If you remember a missed dose within 12 hours of when youd normally take it, take the missed dose. Then carry on with your usual dosing schedule.

If youre more than 12 hours late taking a dose, skip that dose. Then carry on with your usual dosing schedule. Dont take any extra doses to make up for a missed dose.

To help make sure that you dont miss a dose, try using a medication reminder. This can include setting an alarm or timer on your phone or downloading a reminder app. A kitchen timer can work, too.

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Side Effects Requiring Immediate Medical Attention

Along with its needed effects, mirabegron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mirabegron:

More common

Rare

  • pain in the groin or genitals
  • tearing or eyes
  • Blistering, peeling, or loosening of the skin
  • difficulty in passing urine
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • trouble sleeping
  • unusual tiredness or weakness

Myrbetriqs Side Effects Explained

Below, you can find detailed information about one of Myrbetriqs side effects. To learn more about other side effects of this medication, talk with your doctor.

Diarrhea

Diarrhea is one of the more common side effects of Myrbetriq, but it doesnt happen often. To learn more about how often this side effect occurred in clinical studies, see the drugs prescribing information.

In some cases, diarrhea can lead to dehydration. If you have diarrhea with Myrbetriq, its important to stay hydrated by drinking plenty of water.

If you have bothersome or long lasting diarrhea with Myrbetriq, talk with your doctor. They can suggest ways to ease your symptoms.

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What Medications Are Similar

There are a few other medications that are also used to treat OAB, including:

  • Ditropan XL and Ditropan IR

Ditropan XL and Ditropan IR

Oxybutynin is a urinary antispasmodic medication that works by relaxing bladder smooth muscle. It is often prescribed to treat OAB in adults, as well as NDO. Ditropan XL is available as an oral tablet. The most common side effects are urinary tract infection, trouble sleeping, dry mouth, and dizziness.

Detrol

Tolterodine is another urinary antispasmodic that works by relaxing bladder smooth muscle to treat OAB. Detrol is available in tablet and capsule form. Common side effects include dry mouth, headache, dizziness, and constipation.

Vesicare

As another urinary antispasmodic, solifenacin works similarly to Ditropan IR and Detrol . It is often prescribed to treat OAB. The most common side effects include dry mouth, constipation, blurred vision, and urinary retention. This medication is sometimes used in combination with Myrbetriq.

This list is a list of examples of medications used to treat OAB. It is not necessarily a list of drugs recommended to take with Myrbetriq. Ask your healthcare provider if you have any questions.

Dosage For Neurogenic Detrusor Overactivity

Myrbetriq 25 Mg Gallery

Children ages 3 years and older with neurogenic detrusor instability may be prescribed Myrbetriq tablets or granules. NDO is an overactive bladder thats caused by a nerve problem. The form of Myrbetriq used for NDO depends on the childs body weight and how easy they find it to swallow tablets.

Children who weigh less than 35 kg * will be prescribed Myrbetriq granules. The usual dosages are described below:

  • Children weighing 11 kg to less than 22 kg : The usual starting dosage is 24 mg taken once per day. If the childs symptoms dont reduce, their doctor may increase their dosage to a maximum of 48 mg taken once per day.
  • Children weighing 22 kg to less than 35 kg : The usual starting dosage is 32 mg taken once per day. If the childs symptoms dont reduce, their doctor may increase their dosage to a maximum of 64 mg taken once per day.

Children who weigh 35 kg or more may be prescribed Myrbetriq granules or tablets. The usual dosages are described below:

  • For Myrbetriq tablets: The usual starting dosage is one 25 mg tablet taken once per day. If the childs symptoms dont reduce after 4 to 8 weeks, their doctor may increase their dosage to a maximum of 50 mg per day.
  • For Myrbetriq granules: The usual starting dosage is 48 mg taken once per day. If the childs symptoms dont reduce, their doctor may increase their dosage to a maximum of 80 mg taken once per day.

* One kilogram is about 2.2 pounds .

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Dosage For Overactive Bladder

Adults with an overactive bladder will be prescribed Myrbetriq tablets. Theres no recommended dosage of Myrbetriq granules for adults.

The usual starting dosage is one 25-mg tablet taken once per day. If your symptoms dont ease after 4 to 8 weeks, your doctor may increase your dosage to 50 mg per day. This is the maximum recommended dosage.

For OAB, you may take Myrbetriq alone, or you may take it with another drug called solifenacin . The recommended dosage of Myrbetriq is the same in both cases.

Who Can And Cannot Take Mirabegron

Mirabegron can be taken by adults .

It is not suitable for everyone. To make sure it’s safe for you, tell your doctor or pharmacist before starting mirabegron if you:

  • have had an allergic reaction to mirabegron or any other medicines in the past
  • have liver or kidney problems
  • have high blood pressure
  • are not able to pee or empty your bladder completely
  • have a blockage in your bladder
  • have a heart problem called QT prolongation
  • are pregnant, trying to get pregnant or breastfeeding

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What Should I Know About Myrbetriq Vs Oxybutynin Vesicare Toviaz Flomax And Other Alternatives

Myrbetriq, oxybutynin, Vesicare, Toviaz, and Flomax are all medications prescribed to treat overactive bladder .

To learn more about these medications, including their uses, side effects, and dosages, talk with your doctor or pharmacist. They can tell you more about how Myrbetriq compares with these and other alternatives.

Myrbetriq: How It Works

Stop Urinary Incontinence with Zero Side Effects, with Bladder Training?

Myrbetriq is approved to treat the conditions below:

  • Overactive bladder . Myrbetriq is used in adults with OAB who have urinary urgency, frequency, and incontinence.
  • Neurogenic detrusor overactivity . Myrbetriq is used in children ages 3 years and older with neurogenic detrusor overactivity. NDO is a type of overactive bladder thats caused by a nerve problem.

To learn more about these conditions, see the Myrbetriq: Uses section above.

Myrbetriq belongs to a drug class called beta-3 agonists. The drug works* by attaching to beta-3 cells on the bladder. This allows the bladder muscles to relax, helping it to hold more urine. This is how Myrbetriq eases the symptoms of OAB and NDO.

* The way a drug works in your body is called its mechanism of action.

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Myrbetriq: Questions For Your Doctor

If you have questions about taking Myrbetriq, talk with your doctor. They can help advise whether Myrbetriq could be a good treatment option for you. Heres a list of questions you may want to ask your doctor:

  • How is Myrbetriq different from other drugs that treat overactive bladder ?
  • Will Myrbetriq interact with any medications Im taking?
  • How can I manage side effects I may have with Myrbetriq?

Your doctor may also tell you about other treatment options for your condition. Check out our selection of videos on OAB.

Disclaimer: Healthgrades has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Mild And Serious Side Effects

Mild and serious side effects of Myrbetriq are listed in the table below. These side effects may vary depending on whether Myrbetriq is taken alone or in combination with other medications. This table does not include all of Myrbetriqs possible side effects.

Mild side effects*
eye problems, such as blurry vision or dry eyes

* This is not a complete list of Myrbetriqs mild side effects. To learn about other mild side effects of this drug, ask your doctor or pharmacist. You can also check side effects in the drugs prescribing information. For more information about this side effect, see Myrbetriqs side effects explained below.

Most times, mild side effects of a drug go away within a few days or a couple of weeks. Talk with your doctor or pharmacist if any side effects dont go away or become severe.

Serious side effects from Myrbetriq arent common, but they are possible. If you have serious side effects, call your doctor right away. However, if youre having a medical emergency or your symptoms feel life threatening, call 911 or a local emergency number.

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Use Of Myrbetriq And Important Safety Information

Do not take MYRBETRIQ® if you are allergic to mirabegron or any ingredients in MYRBETRIQ. MYRBETRIQ may cause your blood pressure to increase or make your blood pressure worse if you have a history of high blood pressure. You and your doctor should check your blood pressure while you are taking MYRBETRIQ.

Can Myrbetriq Cause Dementia

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No, Myrbetriq isnt known to cause dementia.

A class of drugs called antimuscarinics has been found to increase the risk of dementia in older people. Like Myrbetriq, antimuscarinics are used to treat overactive bladder. But Myrbetriq isnt an antimuscarinic, and its not known to have this risk.

If you have any concerns about dementia during your Myrbetriq treatment, talk with your doctor.

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Tell The Prescribing Healthcare Provider About All Medical Conditions

Many adverse effects are caused by underlying physical conditions. It always helps to make sure that the prescribing healthcare provider has a complete medical history. When prescribing Myrbetriq, they should particularly be informed about:

  • Uncontrolled and severe high blood pressure
  • Difficulty emptying the bladder or a weak stream during urination
  • Any history of hereditary angioedema
  • Pregnancy or any pregnancy plans
  • Breastfeeding or plans to breastfeed

What Are The Side Effects Of Myrbetriq

This is not a complete list of side effects and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the Food and Drug Administration at www.fda.gov/medwatch or 800-FDA-1088.

Like most medications, Myrbetriq can cause mild or severe side effects.

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Financial And Insurance Assistance

If you need financial support to pay for Myrbetriq, or if you need help understanding your insurance coverage, help is available.

Astellas Pharma US Inc., the manufacturer of Myrbetriq, offers a program called Momentum. Through this program, you can find information on ways to save on Myrbetriq. For more information and to find out if youre eligible for support, visit the program website.

You can also check out the Astellas Patient Assistance Programs website to learn about other financial support options available for Myrbetriq.

Myrbetriq And Other Medications

Astellas – Myrbetriq bladder character advertisement

Below is a list of medications that can interact with Myrbetriq. This list does not contain all drugs that may interact with Myrbetriq.

Before taking Myrbetriq, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Types of drugs that can interact with Myrbetriq include:

  • Drugs that are metabolized by CYP2D6. CYP2D6 is an enzyme in your liver that helps your body break down certain drugs. Myrbetriq can stop this enzyme from working correctly. Taking Myrbetriq with these drugs can increase the risk of their side effects. Examples of these drugs include:
  • Digoxin . Digoxin is a drug used to treat certain heart problems, such as heart failure and atrial fibrillation. Taking Myrbetriq with digoxin can increase the risk of digoxin side effects. Your doctor may prescribe a lower dose of digoxin than usual.
  • Recommended Reading: What Medications Can Cause Overactive Bladder

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