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How Fatal Is Bladder Cancer

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It’s also helpful for them to know whether or not you have any pain when you pass the urine with the blood.

While blood in your urine is the main sign, the experts said you should also lookout for these six symptoms.

  • passing urine very often
  • passing urine very suddenly
  • pain or a burning sensation when passing urine
  • weight loss for no reason
  • pain in your back, lower tummy or bones
  • feeling tired and unwell.
  • They explained that the final three may occur if the cancer is advanced or has spread to other parts of the body.

    In men, it’s also important to note that prostate cancer can cause urinary symptoms.

    It’s important to note that experiencing these symptoms won’t always mean you have cancer.

    For example, the experts said that they might also be a sign of a urine infection.

    This might be the case, particularly if you do not have blood in your urine, they said.

    “For men, the symptoms could be caused by an enlarged prostate gland.

    What Affects Survival Rate And What Treatment Options Are Available

    After diagnosing bladder cancer, your doctor will try to determine if it has advanced and if it has, how far. Doctors use a staging process to describe how far the tumor has penetrated the surrounding tissue and muscle, and to what extent it has spread to other parts of the body or metastasized. The staging process helps the doctor decide on the best way to treat it.

    The American Joint Committee on Cancer TNM system is the most widely used staging system for bladder cancer. It relies on three critical factors:

    • T: The letter “T” stands for “tumor” and describes the degree to which the tumor has grown through the wall of your bladder and into neighboring tissue and muscles.
    • N: The letter “N” stands for “nodes” and notes if the cancer has spread to nearby lymph nodes. Lymph nodes are groups of immune system cells about the size of beans. When cancer starts to spread, it frequently spreads to the lymph nodes nearest the bladder first.
    • M: The letter “M” stands for “metastasized,” which means the cancer has spread to other parts of the body, such as the liver, lungs or other lymph nodes farther from the bladder.

    The American Cancer Society provides a detailed breakdown of the TNM system. Letters or numbers after T, N and M offer more detail related to the progression of the cancer.

    The Following Stages Are Used For Bladder Cancer:

    Stage 0

    In stage 0, abnormalcells are found in tissue lining the inside of the bladder. These abnormal cells may become cancer and spread into nearby normal tissue. Stage 0 is divided into stages 0a and 0is, depending on the type of the tumor:

    • Stage 0a is also called noninvasive papillary carcinoma, which may look like long, thin growths growing from the lining of the bladder.
    • Stage 0is is also called carcinoma in situ, which is a flat tumor on the tissue lining the inside of the bladder.

    Stage I

    In stage I, cancer has formed and spread to the layer of connective tissue next to the inner lining of the bladder.

    Stage II

    In stage II, cancer has spread to the layers of muscle tissue of the bladder.

    Stage III

    Stage III is divided into stages IIIA and IIIB.

  • In stage IIIB, cancer has spread from the bladder to more than one lymph node in the pelvis that is not near the common iliac arteries or to at least one lymph node that is near the common iliac arteries. Enlarge Stage IIIB bladder cancer. Cancer has spread from the bladder to more than one lymph node in the pelvis that is not near the common iliac arteries or at least one lymph node that is near the common iliac arteries.
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    Can A Turbt Cure Bladder Cancer

    Transurethral resection with fulguration is usually the first treatment for these cancers. But its done to help determine the extent of the cancer rather than to try to cure it. If no other treatment is given, many people will later get a new bladder cancer, which often will be more advanced. This is more likely to happen if the first cancer is high-grade .

    Is Bladder Cancer A High Risk Disease

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    Bladder cancer has a tendency to recur, so when treatment ends, youre still considered at high risk. Some people with superficial bladder cancer experience frequent recurrences throughout their lives. In general, the prognosis is worse. when recurrence involves distant tissues, organs, or lymph nodes.

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    Other Squamous Cell Carcinoma Risk Factors

    Having bladder diverticula may increase an individuals chance of developing SCC. Rarely, bacillus Calmette-Guerin treatment for CIS has been reported to lead to development of SCC. Development of bladder cancer at a younger age has been associated with bladder exstrophy. SCC has also been described in urachal remnants.

    Coffee consumption does not increase the risk of developing bladder cancer. Early studies of rodents and a minority of human studies suggested a weak connection between artificial sweeteners and bladder cancer however, most recent studies show no significant correlation.

    What Is Muscle Invasive Bladder Cancer

    Muscle invasive bladder cancer is a cancer that spreads into the detrusor muscle of the bladder. The detrusor muscle is the thick muscle deep in the bladder wall. This cancer is more likely to spread to other parts of the body.

    In the U.S., bladder cancer is the third most common cancer in men. Each year, there are more than 83,000 new cases diagnosed in men and women. About 25% of bladder cancers are MIBC. Bladder cancer is more common as a person grows older. It is found most often in the age group of 75-84. Caucasians are more likely to get bladder cancer than any other ethnicity. But there are more African-Americans who do not survive the disease.

    What is Cancer?

    Cancer is when your body cells grow out of control. When this happens, the body cannot work the way it should. Most cancers form a lump called a tumor or a growth. Some cancers grow and spread fast. Others grow more slowly. Not all lumps are cancers. Cancerous lumps are sometimes called malignant tumors.

    What is Bladder Cancer?

    When cells of the bladder grow abnormally, they can become bladder cancer. A person with bladder cancer will have one or more tumors in his/her bladder.

    How Does Bladder Cancer Develop and Spread?

    The bladder wall has many layers, made up of different types of cells. Most bladder cancers start in the urothelium or transitional epithelium. This is the inside lining of the bladder. Transitional cell carcinoma is cancer that forms in the cells of the urothelium.

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    Prognosis And Survival Rates For Bladder Cancer

    When someone is diagnosed with bladder cancer, their doctor will give them a prognosis. A prognosis is the doctors opinion of how likely the cancer will spread and the chances of getting better. A prognosis depends on the type and stage of cancer, as well as the persons age and general health.

    Bladder cancer can usually be effectively treated if it is found before it spreads outside the bladder.

    If you have bladder cancer, your doctor will talk to you about your individual situation when working out your prognosis. Every persons experience is different, and there is support available to you.

    B Searching For The Evidence: Literature Search Strategies For Identification Of Relevant Studies To Answer The Key Questions

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    Publication Date Range

    Searches will begin in January 1990, a date early enough to capture all relevant published studies of current treatments for bladder cancer.

    Library searches will be updated while the draft report is posted for public comment and peer review to capture any new publications. Literature identified during the update search will be assessed by following the same process of dual review as all other studies considered for inclusion in the report. If any pertinent new literature is identified for inclusion in the report, it will be incorporated before the final submission of the report.

    Literature Databases

    Ovid MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Health Technology Assessment, National Health Sciences Economic Evaluation Database, and Database of Abstracts of Reviews of Effects will be searched to capture both published and grey literature. See Appendix A for the primary Ovid MEDLINE search strategy.

    Scientific Information Packets

    Manufacturers of currently available and FDA approved diagnostic biomarkers for diagnosis and surveillance of bladder cancer, and treatments for Non-MIBC will be invited to provide SIPs.

    Hand Searching

    Reference lists of included articles will also be reviewed for includable literature. Searches will also be supplemented by suggestions from the TEP.

    Contacting Authors

    Process for Selecting Studies

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    Symptoms Of Bladder Cancer

    Blood in your urine is the most common symptom of bladder cancer.

    The medical name for this is haematuria and it’s usually painless. You may notice streaks of blood in your urine or the blood may turn your urine brown. The blood isn’t always noticeable and it may come and go.

    Less common symptoms of bladder cancer include:

    • a need to urinate on a more frequent basis
    • sudden urges to urinate
    • a burning sensation when passing urine

    If bladder cancer reaches an advanced stage and begins to spread, symptoms can include:

    • swelling of the legs

    Faq What Is A Positive Resection Margin

    Rim of tissue called the surgical margin or margin of resection.

    The surgeons goal during surgery is to remove the cancer along with a rim of normal tissue around it. This is to ensure that all of the cancer has been removed.

    During or after surgery, a pathologist examines this rim of tissue called the surgical margin or margin of resection to be sure its clear of any cancer cells. If cancer cells are present, this will influence decisions about treatments such as additional surgery and radiation.

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    After Bladder Cancer Has Been Diagnosed Tests Are Done To Find Out If Cancer Cells Have Spread Within The Bladder Or To Other Parts Of The Body

    The process used to find out if cancer has spread within thebladder lining and muscle or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. The following tests and procedures may be used in the staging process:

    Diagnosis Of Bladder Cancer

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    Your doctor will take a detailed medical history and ask questions about your symptoms. You can help your doctor by preparing for the consultation:

    • Make a list of your previous surgical procedures.
    • Make a list of the medications that you take.
    • Mention other diseases and allergies that you have.
    • Describe your lifestyle, including exercise, smoking, alcohol, and diet.
    • Describe your current symptoms.
    • Note how long you have had the current symptoms.
    • Family history of other tumours, especially in the urinary tract.

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    How Do You Prevent Bladder Cancer

    Unfortunately, there is no one way to prevent bladder cancer. Some things like age, race, gender and genetics or family history cant be controlled. However, people can take steps to reduce their risk.

    Tips for bladder cancer prevention include:

    • Quit or dont start smoking
    • Limit chemical exposure on the job
    • Drink plenty of fluids, especially water
    • Eat a diet high in fruits and vegetables

    What Is The Survival Rate

    Metastatic bladder cancer is difficult to cure because it has already traveled to other parts of the body. The later you receive a diagnosis and the farther the cancer has traveled, the less chance it can be cured.

    The 5-year survival rate is the proportion of people who survive for 5 years after a cancer diagnosis.

    For bladder cancer, if the cancer has spread to the regional lymph nodes, the 5-year survival rate is

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    Rationale For Evidence Review

    The comparative effectiveness of the diagnostic tests and treatments for Non-MIBC is uncertain. Existing guidelines for the treatment and follow up of Non-MIBC from the European Association of Urology were published in 2011.11 Since publication of that review there have been numerous randomized controlled trials, controlled clinical trials, comparative studies and cohort studies. Much of this literature focuses on diagnostic techniques such as fluorescence cystoscopy or urine-based biomarkers, and treatments with intravesical therapy including mitomycin and BCG. A systematic evidence review that includes recently published research may provide a better understanding of the comparative effectiveness of these approaches to diagnosis, treatment, and post-treatment surveillance for Non-MIBC. The systematic review may be used to update existing clinical recommendations that are several years old and may be out of date due to the development of new technologies and therapies.

    What Is The Five Year Survival Rate For Bladder Cancer

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    A five-year survival rate is the percentage of people in a study or treatment group who are alive five years after they were diagnosed with or started treatment for a disease such as bladder cancer. Their disease may or may not have recurred during that time.

    The American Cancer Society periodically reports on the five-year survival rate for bladder cancer. The most recently period studied was from 2010 to 2016 and that rate was 77%. This means that from the time of diagnosis, 77 out of 100 people diagnosed with bladder cancer were alive in five years. From 1987 1989 , the five-year survival rate was 79% and from 1975 1977, it was 72%. The survival rates are not the same for everyone, however.

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    A Criteria For Inclusion/exclusion Of Studies In The Review

    The criteria for inclusion and exclusion of studies will be based on the Key Questions and discussion with TEP members, and are described in the previous PICOTS section.

    Below are additional details on the scope of this project:

    Study Designs

    For KQ1, KQ 3, KQ 4, KQ 6, KQ 7 and KQ 8 we will include randomized controlled trials and cohort studies with comparators if RCTs are not available. For KQ 2 and KQ 5, studies that report diagnostic accuracy will be included. For all KQs we will exclude uncontrolled observational studies, case-control studies, case series, and case reports, as these studies are less informative than studies with a control group.

    Systematic reviews will be used as primary sources of evidence if they address a key question and are assessed as being at low risk of bias, according to the AMSTAR quality assessment tool.12,13 If systematic reviews are included, we will update findings with any new primary studies identified in our searches, update meta-analyses if appropriate, and re-assess SOE based on the totality of evidence. If multiple systematic reviews are relevant and low risk of bias, we will focus on the findings from the most recent reviews and evaluate areas of consistency across the reviews.14,15


    Non-English Language Studies

    For Connecting And Sharing During A Cancer Journey

    Anyone with cancer, their caregivers, families, and friends, can benefit from help and support. The American Cancer Society offers the Cancer Survivors Network , a safe place to connect with others who share similar interests and experiences. We also partner with CaringBridge, a free online tool that helps people dealing with illnesses like cancer stay in touch with their friends, family members, and support network by creating their own personal page where they share their journey and health updates.

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    Survival Rates For Bladder Cancer

    Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time after they were diagnosed. They cant tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

    Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they cant predict what will happen in any particular persons case. These statistics can be confusing and may lead you to have more questions. Your doctor is familiar with your situation ask how these numbers may apply to you.

    What Is The Life Expectancy For Bladder Cancer

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    Bladder Cancer Bladder cancer originates within the bladder, and may have several different causes, including. smoking, workplace chemical exposures, diet, and. the herb Aristolochia fangchi. Though there are several types of bladder cancer, cancer is most likey to develop in the interior lining of the bladder.

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    Local Recurrence Of Bladder Cancer

    Local recurrence takes place in the soft tissue where the bladder has been before removal or at the site of the lymph nodes that were removed. This is due to the fact that even after removal of the local pelvic lymph nodes, some nodes are left in place. Most local recurrences appear within the first 2 years. Local recurrence after complete removal of the urinary bladder is associated with poor overall prognosis but can occasionally be treated .

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