Understanding The Statistics: Cancer Survival
It is important to remember that all cancer survival numbers are based on averages across huge numbers of people. These numbers cannot predict what will happen in your individual case.
Survival rates will not tell you how long you will live after you have been diagnosed with bladder cancer. But, these numbers can give you an idea of how likely your treatment will be successful. Also, survival rates take into account your age at diagnosis but not whether you have other health conditions too.
What Impacts The Bladder Cancer Survival Rate
Survival rates depend on many factors, including the type and stage of bladder cancer that is diagnosed. According to the ACS, the five-year survival rate of people with bladder cancer that has not spread beyond the inner layer of the bladder wall is 96%. This is called non-muscle invasive bladder cancer . More than half of people are diagnosed at this stage.
If a tumor is invasive but has not yet spread outside the bladder, the five-year survival rate is 69%. Approximately 33% of bladders cancers are diagnosed at this stage. If the cancer extends through the bladder to the surrounding tissue or has spread to nearby lymph nodes or organs, the five-year survival rate is 37%. If the cancer has spread to distant parts of the body, the five-year survival rate is 6%. About 4% of people are diagnosed at this stage.
It is important to remember that statistics about the five-year survival rates for people with bladder cancer are estimates only and come from annual data based on the number of people with this cancer. A number of new and promising bladder cancer treatments that have been approved by the Food and Drug Administration in the last five years might not be reflected in a five-year survival rate statistic.
Just like no single treatment is appropriate for all bladder cancer patients, there is not one statistic that applies to everyone either. Talk with your doctor about your own individual situation to gain the best understanding you can.
Distant Bladder Cancer Metastasis
Once cancerous cells have reached the lymphatic system, they can make their way to almost any part of the body. However, the most common sites for distant bladder cancer metastases include the:
Metastatic bladder cancer can also spread to other organs in the urinary and reproductive tracts, such as the prostate, uterus and vagina.
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Prognosis And Survival For Bladder Cancer
If you have bladder cancer, you may have questions about your prognosis. A prognosis is the doctors best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. Only a doctor familiar with your medical history, the type and stage and other features of the cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis.
A prognostic factor is an aspect of the cancer or a characteristic of the person that the doctor will consider when making a prognosis. A predictive factor influences how a cancer will respond to a certain treatment. Prognostic and predictive factors are often discussed together. They both play a part in deciding on a treatment plan and a prognosis.
The following are prognostic and predictive factors for bladder cancer.
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What Is The Prognosis For Metastatic Bladder Cancer
Most people with metastatic bladder cancer cannot be cured. The 5-year relative survival rates for people with distant bladder cancer, meaning the cancer has spread to distant parts of the body such as the lungs, liver, or bones, is about 5 percent. This means that people with metastatic bladder cancer are, on average, about 5 percent as likely as people who do not have this form of cancer to live for at least 5 years after being diagnosed.1,5
However, there are treatments available that can help some people with metastatic bladder cancer to live longer and improve their quality of life.1
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Bladder Cancer Survival By Age
Five-year survival for bladder cancer is generally higher in younger men and women and decreases with increasing age. Five-year net survival in men ranges from 73% in 15-49 year-olds to 43% in 80-99 year-olds for patients diagnosed with bladder cancer in England during 2009-2013. In women, five-year survival ranges from 57% in 50-59 year-olds to 31% in 80-99 year-olds.
Bladder Cancer , Five-Year Net Survival by Age, England, 2009-2013
What Is Muscle Invasive Bladder Cancer
Muscle invasive bladder cancer is a cancer that spreads into the detrusor muscle of the bladder. The detrusor muscle is the thick muscle deep in the bladder wall. This cancer is more likely to spread to other parts of the body.
In the U.S., bladder cancer is the third most common cancer in men. Each year, there are more than 83,000 new cases diagnosed in men and women. About 25% of bladder cancers are MIBC. Bladder cancer is more common as a person grows older. It is found most often in the age group of 75-84. Caucasians are more likely to get bladder cancer than any other ethnicity. But there are more African-Americans who do not survive the disease.
What is Cancer?
Cancer is when your body cells grow out of control. When this happens, the body cannot work the way it should. Most cancers form a lump called a tumor or a growth. Some cancers grow and spread fast. Others grow more slowly. Not all lumps are cancers. Cancerous lumps are sometimes called malignant tumors.
What is Bladder Cancer?
When cells of the bladder grow abnormally, they can become bladder cancer. A person with bladder cancer will have one or more tumors in his/her bladder.
How Does Bladder Cancer Develop and Spread?
The bladder wall has many layers, made up of different types of cells. Most bladder cancers start in the urothelium or transitional epithelium. This is the inside lining of the bladder. Transitional cell carcinoma is cancer that forms in the cells of the urothelium.
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What Causes Bladder Cancer And Am I At Risk
Each year, about 83,730 new cases of bladder cancer will be diagnosed in the United States. It affects more men than women and the average age at diagnosis is 73.
Cigarette smoking is the biggest risk factor for bladder cancer. About half of all bladder cancers are caused by cigarette smoking. Other risk factors for developing bladder cancer include: family history, occupational exposure to chemicals , previous cancer treatment with cyclophosphamide, ifosfamide, or pelvic radiation, the medication pioglitazone, exposure to arsenic , aristolochic , bladder infections caused by schistosoma haematobium, not drinking enough fluids, a genetic condition called Lynch Syndrome, a mutation of the retinoblastoma gene or the PTEN gene. and neurogenic bladder and the overuse of indwelling catheters.
How We Care For You
The symptoms of liver metastases are often vague and hard to identify yourself. If you have any concerns, contact your doctor. Memorial Sloan Kettering has a team of specialists who are very experienced in diagnosing and treating the condition.
- Our goal is to provide treatment options that give you the very best possible quality of life and survival rate.
- MSK surgeons work closely with interventional radiologists in using powerful imaging tests such as CT, ultrasound, or MRI to guide treatments directly to where your tumor is located. We can often destroy tumors with minimally invasive techniques, such as ablation and embolization.
- Through genetic testing of tumors, we learn about the molecular blueprint of your particular cancer and customize a treatment plan for you. Another option is to combine surgery with hepatic arterial chemotherapy, which delivers the drug directly to the liver.
We also offer a range of support programs that can help you and your loved ones manage the challenges and stress of life during and after treatment for liver cancer.
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What Are The Layers Of The Bladder
The bladder consists of three layers of tissue. The innermost layer of the bladder, which comes in contact with the urine stored inside the bladder, is called the mucosa and consists of several layers of specialized cells called transitional cells, which are almost exclusively found in the urinary system of the body. These same cells also form the inner lining of the ureters, kidneys, and a part of the urethra. These cells form a waterproof lining within these organs to prevent the urine from going into the deeper tissue layers. These cells are also termed urothelial cells, and the mucosa is termed the urothelium.
The middle layer is a thin lining known as the lamina propria and forms the boundary between the inner mucosa and the outer muscular layer. This layer has a network of blood vessels and nerves and is an important landmark in terms of the staging of bladder cancer .
The outer layer of the bladder comprises of the detrusor muscle. This is the thickest layer of the bladder wall. Its main function is to relax slowly as the bladder fills up to provide low-pressure urine storage and then to contract to compress the bladder and expel the urine out during the act of passing urine. Outside these three layers is a variable amount of fat that lines and protects the bladder like a soft cushion and separates it from the surrounding organs such as the rectum and the muscles and bones of the pelvis.
Genetic Factors In Pathogenesis
Divergent, yet interconnected and overlapping, molecular pathways are likely responsible for the development of noninvasive and invasive bladder tumors. Somatic mutations in fibroblast growth receptor3 and tumor protein p53 in tumor cells appear to be important early molecular events in the noninvasive and invasive pathways, respectively.
FGFR-3, Ras, and PIK3CA mutations occur with high frequency in noninvasive tumors, leading to upregulation of Akt and mitogen-activated protein kinase . Loss of heterozygosity on chromosome 9 is among the most frequent genetic alterations in bladder tumors and is considered an early event.
Large numbers of genomic changes have been detected using karyotyping and comparative genomic hybridization analysis in urothelial carcinoma. Numerically common are losses of 2q, 5q, 8p, 9p, 10q, 18q, and Y. Gains of 1q, 5p, 8q, and 17q are frequently present, and high-level amplifications can be found however, the target genes in the regions of amplifications have not been conclusively identified.
Alterations in the TP53 gene are noted in approximately 60% of invasive bladder cancers. Progression-free survival is significantly shorter in patients with TP53 mutations and is an independent predictor of death among patients with muscle-invasive bladder cancer.
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Metastatic Bladder Cancer Survival: Impact Of Race And Sex
For a study, researchers sought to describe the epidemiological profile of metastatic bladder cancer and evaluate the death rates for the 3 most prevalent bladder cancer histologiesTransitional Cell Carcinoma, Adenocarcinoma, and SCC according to racial and gender factors.
All patients with metastatic bladder cancer who were presenting were searched for in the Surveillance, Epidemiology, and End Results Program database . Four racial/gender pairings made up the main exposure. Comparing categorical and continuous variables across the exposure variable was done using one-way ANOVA and Chi-square testing, respectively. The connection between race/gender combinations and the overall and cancer-specific survival was investigated using univariable and multivariable Cox proportional hazards regression analysis, which controlled for the other factors.
A total of 312,846 individuals with bladder cancer, 6,337 who had distant metastases, and 11,446 who had regional metastases were assessed. Compared to all races/gender, black female cancer-specific survival in metastatic disease was disproportionately lower for transitional cell carcinoma 4.3% , SCC 2.6% , and for Adenocarcinoma 6.4% . A higher risk of developing cancer specifically was linked to being a Black female , having SCC , increasing age , and having a poorly differentiated grade .
Bladder Cancer Stages And Survival Rates
Cancer survival rates are also categorized according to the stage of the cancer when it was diagnosed. The stage of cancer generally refers to how far it has progressed, and whether it has spread to other parts of the body. For bladder cancer, the 5-year survival rate for people with:2,3
- Bladder cancer in situ is around 96 percent
- Localized bladder cancer is around 70 percent
- Bladder cancer that has spread to the regional lymph nodes is 35 percent
- Distant or metastasized bladder cancer is 5 percent
If you would like to learn more about bladder cancer statistics, consider speaking with someone on your health care team. They will be able to explain more about how these statistics apply to your cancer. Tell us about your experience in the comments below, or with the community.
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Overview Of Management Of Muscle Invasive Bca
RC with pelvic lymph node dissection is the standard treatment for patients with non-metastatic MIBC and patients with very high-risk non-muscle invasive BCa . The 5-year overall survival rates were estimated to be around 60% , ranging from 32% in patients with lymph node involvement to 75% in those without . RC includes pelvic lymphadenectomy as an integral part of the procedure with better oncological outcomes in patients with N0M0 MIBC. Indeed, lymph node status is the single most powerful pathologic predictors of long term disease-specific survival and OS, but the exact extent of PLND is a matter of debate with on-going randomized trials adding new knowledge soon . Despite radical treatment, the incidence of distance failure in clinically non-metastatic patients with organ confined, extravesical and lymph node positive disease were estimated to be 25%, 37% and 51%, respectively . This is attributed to the presence of micrometastasis that remains undiagnosed at the time of surgery .
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How Long Will You Live If You Have Bladder Cancer
The survival rate depends on the stage of cancer at diagnosis and other health issues.
Overall, 70 to 90 percent of people with localized bladder cancer will live for at least five years or more. The physician calculates this with the help of survival rates. Survival rates indicate the percentage of people who live with a certain type of cancer for a specific time. The physician often uses an overall five-year survival rate. Factors that may affect survival rate include
Table. Five-year survival rates of different stages of bladder cancer
|Bladder cancer SEER stages||Five-year relative survival rate|
|In situ alone||96|
|All SEER stages combined||77|
The surveillance, epidemiology, and end results stages are taken from the SEER database, maintained by the National Cancer Institute. SEER database groups cancers into localized, regional, and distant stages.
- Localized: There is no indication that cancer has spread outside the bladder.
- Regional: Cancer has invaded the nearby structures or lymph nodes.
- Distant: Cancer has spread to distant parts of the body, such as the lungs, liver, or bones.
Thus, bladder cancer, if detected in the early stage is treatable and has higher survival rates. However, if the cancer is detected in the advanced stages, treatment becomes difficult and the survival rate is low.
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Side Effects Of Treatment For Bladder Cancer
All cancer treatments can have side effects. Your treatment team will discuss these with you before you start treatment. Talk to your doctor or nurse about any side effects you are experiencing. Some side effects can be upsetting and difficult, but there is help if you need it.
or email to speak with a caring cancer nurse for support.
Risk Factors For Bladder Cancer
There are some things that can make you more likely to develop bladder cancer. These are called risk factors and they include:
- smoking chemicals in cigarettes can cause bladder cancer, so if you smoke, your risk is up to 3 times that of a non-smoker
- age most people with bladder cancer are over 60 years of age
- being male men are around 3 times more likely than women to develop bladder cancer
- chemicals being in contact with certain chemicals for a long period of time, like aromatic amines, benzene products and aniline dyes, which have been linked to bladder cancer
- chronic infections frequent infections of the bladder over a long period of time
- previous cancer treatments some types of radiation therapy around the pelvis, and the chemotherapy drug cyclophosphamide
- family history a first degree relative with bladder cancer increases risk up to nearly 2 times higher than the general population.
Having these risk factors doesnt mean you will develop bladder cancer. Often there is no clear reason for getting bladder cancer. If you are worried about your risk factors, ask your doctor for advice.
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What Is Stage 4 Bladder Cancer
Being diagnosed with bladder cancer can be overwhelming, especially if its stage 4.
Stage 4 bladder cancer is the most advanced stage and carries the worst prognosis. Many cancer treatments will be both difficult and challenging.
However, treatment can reduce or even eliminate your symptoms and help you live a longer, more comfortable life.
Its important to consider the pros and cons of treating stage 4 bladder cancer because treatments come with side effects and risks.
Symptoms of bladder cancer can include:
- blood or blood clots in your urine
- pain or burning during urination
- frequent urination
- needing to urinate at night
- needing to urinate but not being able to
- lower back pain on one side of the body
These symptoms commonly lead to a diagnosis, but they arent unique to stage 4 bladder cancer.
Stage 4 bladder cancer is also called metastatic bladder cancer. This means the cancer has spread outside of the bladder into other parts of the body.
People with metastatic cancer may experience symptoms relating to where the cancer has spread. For example, if a persons bladder cancer has spread to their lungs, they may experience chest pain or increased coughing.
Metastatic bladder cancer is difficult to cure because it has already traveled to other parts of the body. The later youre diagnosed and the farther the cancer has traveled, the less chance that your cancer will be cured.
The 5-year survival rate is the rate of surviving for 5 years after a cancer diagnosis.