Anthrone And Its Derivatives
Gambogic acid, extracted from gamboges, has an anthrone-derived structure, induces ROS, and promotes a dramatic autophagic response via the JNK pathway. Gambogic acid induces ROS-mediated caspases activation, leading to the degradation of autophagic proteins, and causes mitochondrial hyperpolarization and caspase activation, which triggers the intrinsic apoptotic pathway. In addition, gambogic acid suppresses NF-B activation through ROS-mediated suppression of IB phosphorylation in T24 and UMUC3 bladder cancer cell lines .
Gartanin, a naturally occurring xanthone, has anticancer activity in various bladder cancer cell lines including HT1376, T24, 5637, TCCSUP, RT4, UMUC3and J82 cells . The underlying molecular mechanism of gartanin involves a marked suppression of eukaryotic translation initiation factor 4E binding protein 1 and p70S6 expression in T24 and RT4 cells. Further, triggering of mTOR pathway-mediated autophagy in T24 and RT4 cells has also been observed. In addition, gartanin downregulates protein expression of the apoptosis inhibitor Bcl-2, whereas it activates the p53 pathway, inducing apoptosis .
Treatment Of Bladder Cancer By Stage
Most of the time, treatment of bladder cancer is based on the tumors clinical stage when it’s first diagnosed. This includes how deep it’s thought to have grown into the bladder wall and whether it has spread beyond the bladder. Other factors, such as the size of the tumor, how fast the cancer cells are growing , and a persons overall health and preferences, also affect treatment options.
What Is Bladder Cancer
Bladder cancer is a fairly common condition that involves your bladder, or the organ in your pelvic region that contains urine. The condition generally begins in the cells that line the bladder and may spread to other parts of your system.While it is often unclear what causes bladder cancer, several related factors have been identified. Some of the primary suspects for causing cancer include smoking, parasitic infection, radiation, and chemical exposure. In any case, some factor causes the cells in your bladder to grow and divide abnormally. This abnormal growth leads to the development of a tumor or mass of abnormal cells.
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Chinese Herbal Medicine Fights Bladder Cancer
- 19 03 March 2013
A new discovery finds that herbs commonly used by licensed acupuncturists have important anti-cancer abilities. New research concludes that the Chinese Medicine herbal formula Gui Zhi Fu Ling Wan powerfully and selectively kills cancer cells while exhibiting minimal toxicity to normal cells. Researchers discovered that the herbal formula potently inhibits the proliferation of bladder cancer cells when administered directly into the bladder. They also found that Gui Zhi Fu Ling Wan selectively kills cancer cells while leaving normal bladder cells unharmed and that the herbal formula prevents the proliferation of cancer cells by blocking cell cycle replication, a process by which cells divide and then duplicate.
Many intravesical chemotherapy agents used in the treatment of bladder cancer lead to blood in the urine, frequent urination, urgent urination, cystitis and other complications. The study found that the Chinese Medicine herbal formula Gui Zhi Fu Ling Wan inhibited the growth of cancer cells but did not cause unwanted side effects. The researchers chose to study Gui Zhi Fu Ling Wan because of its documented ability to inhibit the growth of hepatocellular carcinoma and cervical cancer. Particular interest was in one of the chief ingredients within the herbal formula, Mu Dan Pi . Prior research documented the ability of Mu Dan Pi to induce apoptosis, cell death, in liver cancer cells.
Bladder Cancer Treatment Symptoms: Diarrhea
Diarrhea is also associated with bladder cancer treatment. Stay hydrated as much as possible to replace the fluid loss that comes with diarrhea. Before drinking carbonated liquids, let them lose their fizz since carbonation contributes to gas and discomfort.
Consume smaller meals and replace your electrolytes like potassium and sodium through apricots, bananas, broth and nuts. Consume low-fiber, lower-residue foods too. Drink your beverages and eat foods at room temperature, and try to avoid:
Greasy and spicy foods
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Jelmyto: Fda Approved First Therapy For Low
On April 15, 2020, the U.S. The Food and Drug Administration also approved Jelmyto , the first therapy to treat low-grade upper tract urothelial cancer . Urothelial cancer is a cancer of the lining of the urinary system.
Richard Pazdur, M.D., director of the FDAs Oncology Center of Excellence and acting director of the Office of Oncologic Diseases in the FDAs Center for Drug Evaluation and Research says, This is the first approval specifically for patients with low-grade UTUC and provides an option for some patients who may otherwise require a nephroureterectomy, said Pazdur. Due to substantial treatment challenges associated with the complex anatomy of the upper urinary tract, many patients need to be treated with radical surgery usually complete removal of the affected kidney, ureter and bladder cuff. Jelmyto gives patients, for the first time, an alternative treatment option for low-grade UTUC.
Patients with low grade upper tract tumors FINALLY have treatment, when none existed ever before. Read the full Jelmyto Press Release.
What Are The Alternatives To Radical Cystectomy For The Treatment Of Bladder Cancer
See the list below:
Transurethral resection of bladder tumor alone: Risks include incomplete resection, a high rate of disease recurrence, and the potential for disease progression.
Systemic chemotherapy in combination with TURBT
This regimen has historically included methotrexate, vinblastine, doxorubicin , and cisplatin .
A doublet of gemcitabine and cisplatin has shown similar response rates to MVAC in the metastatic setting and is easier to tolerate therefore, this regimen is often considered the first-line therapy.
Primary radiation therapy: This therapy is more commonly used in countries outside the United States for patients with T2 and T3 cancer. The 5-year survival rate is 20%-40% .
Bladder-sparing multimodality therapy
Transurethral resection plus radiation therapy and concomitant cisplatin-based chemotherapy carries a 3- to 5-year estimated survival rate of 45%-64%. Delayed cystectomy is often required for palliation of symptoms or for recurrent disease. At 5 years following treatment, approximately 40% of patients are disease-free with their native bladder.
No significant improvement over up-front cystectomy has been shown, and the burden of therapy is often greater in patients who undergo multimodal therapy.
This therapy is considered only in patients who are highly motivated to preserve their bladder and reliably adhere to the rigorous surveillance protocol required.
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Types Of Bladder Cancer
Based on the extent of spread of the cancer, bladder cancer is usually classified as:
Based on how the cancer cells look under the microscope, this cancer may also be classified as:
Patients with metastatic bladder cancer generally have a poor prognosis.
New Treatments For Bladder Cancer In 2020
In 2019 and early 2020, the U.S. Food and Drug Administration approved a number of new drugs for bladder cancer of all stages, and more treatments are on the horizon. Heres a snapshot of whats happening right now in bladder cancer treatment:
Non-muscle invasive bladder cancer treatments
In patients with NMIBC, tumors are confined to the inner cell layer of the bladder and have not invaded the thick muscle tissue of the bladder. NMIBC is usually treated by surgical excision in a procedure known as trans urethral resection of bladder tumor , followed by repeated drug injections into the bladder most commonly with a drug called Bacillus Calmette-Guerin .
BCG is a bacterial vaccine that is primarily used to immunize against tuberculosis, but may also trigger a broader immune response against cancer cells. BCG certainly improves outcomes for patients whose tumors have been resected nevertheless, over a half of these patients will experience recurrence within one year, and some do not respond to BCG at all. Intravesical chemotherapy drugs are used for higher-grade NMIBC.
Newly emerging treatment options for NMIBC include:
Of course, the biggest news for NMIBC is the recent FDA approval of the immune checkpoint drug pembrolizumab for systemic treatment of high grade NMIBC that is not responsive to BCG. In clinical testing, 41% of patients experienced complete responses with median duration of 16 months.
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Conventional Treatments For Bladder Cancer
Current conventional treatments for bladder cancer involve a series of highly invasive medical procedures. Surgery to remove tumors, tissue and whole sections of the bladder itself remain standard treatment for cancer sufferers. This is typically followed with radiation, chemotherapy and drug dependent treatments which further assault the body in an effort to cure the patients cancer.
For those stricken with bladder cancer, the available conventional treatments can seem daunting, adding further physical and emotional stress to an already harrowing diagnosis. Alternative treatments, based on natural and holistic therapies, can help patients fight the cause of the cancer that is attacking their systems, minimizing the need for invasive, and toxic, conventional techniques.
Radiation Therapy For Bladder Cancer Treatment
Radiation is a therapy which involves using high-energy radiation to kill cancer cells. Radiation can be either external or internal, depending upon the type of cancer the patient has. Radiation is sometimes combined with chemotherapy medications after a person has undergone bladder cancer surgery. After surgery, chemotherapy and radiation are sometimes able to completely destroy cancer cells that might otherwise have to be treated using cystectomy.
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Curcumin Suppresses Metastatic Events
Metastatic progression is modulated by direct and indirect mechanisms including receptor-driven interactions of tumor cells with the vessel wall and extracellular matrix proteins, alterations of cytoskeletal dynamics, and epithelial-to-mesenchymal transition , with the activation of motility-related signaling. Adhesion-blocking properties of curcumin were first shown by Sindhwani et al., who reported that curcumin inhibits tumor implantation in a murine bladder tumor model . Concerning the molecular mode of action, human Trop2 from the tumor-associated calcium signal transducer gene family has been described to be a target of curcumin in bladder cancer cells, modulating invasion and migration via PI3K/AKT and EMT .
Matrix-metalloproteinases enhance the ability of tumor cells to penetrate cellular barriers . In bladder cancer, levels of MMP-2 and MMP-9 have been shown to be diminished by curcumin with an increase of tissue inhibitor of metalloproteinase-2 as the relevant underlying mechanism. This suggests an inhibitive influence of curcumin on metastatic progression via MMP pathways .
Dr Nathan Goodyear Md Mdh Abaarm
Dr. Goodyear has practiced Integrative Medicine since 2006. Dr. Goodyear is a Fellow in Functional and Regenerative Medicine and served on the board of the American Functional Medicine Association. Dr. Goodyear is licensed by the Arizona Homeopathic and Integrative Medical Board in the State of Arizona.
Dr. Goodyear received his Bachelor of Arts from Louisiana Tech University and his Doctor of Medicine from LSU Health Sciences Center. He is Board Certified in Obstetrics and Gynecology and served as the Chief Resident in Obstetrics and Gynecology at the University of Tennessee.
Dr. Goodyear is a published author, Man Boob Nationan Integrative medicine approach to low Testosterone published in 2014, and Total Testosterone Transformation published in 2017. Dr. Goodyear has spoken across the country on various topics in Wellness Medicine. Dr. Goodyears passion is to bridge the science of Wellness medicine to the clinical application of Wellness medicine to restore medicine to its original purpose of teaching the body how to healDocre rphè.
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Current Alternatives To Bcg
Research on improving NMIBC therapy has mainly focused on rescue patients who do not respond to BCG therapy, since BCG is truly efficacious in the majority of patients for avoiding recurrence and progression episodes. The alternative treatment options include virus and other bacteria different from BCG as vehicles for specific tumor growth inhibition agents or immunostimulatory components, chemotherapeutic agents, new delivery options for current therapies, and systemic immunotherapies that have to be demonstrated to be efficacious in other types of cancers .
Current alternative research for nonmuscle invasive bladder cancer treatment.
Chemotherapeutic Treatments and Improved Delivery
Different strategies can improve the use of chemotherapy for treating NMIBC. The appearance of new agents, the combination of different chemotherapeutic agents, the use of hyperthermia for improving intravesical instillation, or other strategies have been considered for improving the treatment of intermediate- and high-risk NMIBC patients.
The efficacy of intravesical therapies can also be improved through delivery adaptations such as hyperthermia, electromotive drug administration or new devices.
Checkpoint Inhibitors in Nonmuscle-Invasive BC
Why Alternative Cancer Treatment
Our treatment program is designed to stimulate your immune system to recognize and destroy cancer cells in combination with natural, non-invasive, effective therapies that will take advantage of cancer cells’ weaknesses.
Brio Medical’s natural treatment approach offers patients a holistic way to heal the mind, body, and spirit, using proven non-toxic therapies to target cancer cells while providing essential immune system support. Whether you are searching for a natural cancer treatments plan, a way to rebuild your body after chemotherapy or radiation, an adjunct to traditional natural cancer treatments, or are looking to obtain optimal health to help prevent cancer, Brio Medical has an Intensive Integrative Oncology that will treat cancer naturally with non-toxic therapies.
Are Alternative Cancer Treatments Safe?
Our alternative or integrative cancer therapies are much safer than traditional treatments such as full-dose chemotherapy and radiation because the body is exposed to much less toxicity. Licensed physicians who hold themselves to the highest medical and ethical standards perform all treatments, including the intersection of conventional and alternative cancer treatments such as those we offer at Brio Medical.
Am I a Good Candidate for Alternative Cancer Treatment?
How Do I Know What Alternative Cancer Treatment Is Best For Me?
Are Your Treatments Alternatives To Chemotherapy?
How Do Your Treatments Strengthen The Immune System?
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Natural Does Not Mean Safe
CAM therapies include a wide variety of botanicals and nutritional products, such as herbal and dietary supplements, and vitamins. These products do not have to be approved by the Food and Drug Administration before being sold to the public. Also, a prescription isn’t needed to buy them. Therefore, it’s up to you to decide what’s best for you. Some tips to keep in mind are below.
- Herbal supplements may be harmful when taken by themselves, with other substances, or in large doses. For example, some studies have shown that kava kava, an herb that has been used to help with stress and anxiety, may cause liver damage. And St. John, which some people use for depression, may cause certain cancer drugs to not work as well as they should.
- Tell your doctor if you’re taking any dietary supplements, even vitamins, no matter how safe you think they are. This is very important. Even though there may be ads or claims that something has been used for years, they do not prove that it’s safe or effective. This is even more true when combined with your medicines.
- Talk with your doctor about what you should be eating. It’s common for people with cancer to have questions about different foods to eat during treatment. Yet it’s important to know there isn’t just one food or special diet that has proved to control cancer.
Role Of Diet In Bladder Cancer
Although tobacco smoking and exposure to chemicals are considered as the major risk factors/causes for bladder cancer, diet may also play an important role in increasing or reducing the risk of this cancer. In this blog, we will elaborate on some of the studies carried out by researchers across the world, which evaluated the association between the intake of different types of foods/diet and the risk of bladder cancer.
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Intermediate Risk Early Bladder Cancer
People with intermediate-risk non-muscle-invasive bladder cancer should be offered a course of at least 6 doses of chemotherapy. The liquid is placed directly into your bladder, using a catheter, and kept there for around an hour before being drained away.
You should be offered follow-up appointments at 3, 9 and 18 months, then once every year. At these appointments, your bladder will be checked using a cystoscopy. If your cancer returns within 5 years, you’ll be referred back to a specialist urology team.
Some of the chemotherapy medicine may be left in your urine after treatment, which could severely irritate your skin.
It helps if you sit down to urinate and that you’re careful not to splash yourself or the toilet seat. Always wash the skin around your genitals with soap and water afterwards.
If you’re sexually active, it’s important to use a barrier method of contraception, such as a condom. This is because the medicines may be present in your semen or vaginal fluids, which can cause irritation.
You also shouldn’t try to get pregnant or father a child while having chemotherapy for bladder cancer, as the medicines can increase the risk of having a child with birth defects.
Natural Remedies To Support Bladder Cancer Treatment
Any type of cancer can cause significant symptoms and concern however, bladder cancer is one of the most often overlooked types of cancer despite its aggressive symptoms. If you suspect you may have a bladder issue, your first course of action should be to see a doctor. But, natural remedies, such as baking soda, blackstrap molasses, and lemon, are important treatment supports.
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Nutrition And Bladder Cancer
Good nutrition remains the foundation for all naturally centered healthcare. Through good nutrition we help our bodies stave off sickness, and give our systems the tools they need to recover from any illnesses or disorders that do occur. Patients stricken with bladder cancer can do much to help resolve the cause of the imbalances in their body that triggered the disease through the application of good nutritional practices.
The first step in designing a diet for fighting cancer is to remove those foods that can exacerbate the disorder. Animal products, including red meat, poultry, cured or smoked meats, butter, cheeses and whole milk should be eliminated from the patients diet. Commercial meat and dairy contain large amounts of environmental pollutants, including pesticides, hormones and animal steroids. These chemicals can not only have an adverse effect on a persons general health, they can also serve to feed and support the cancer that patients are trying to fight. Highly processed foods and foods high in refined sugars and sodium should also be avoided. These foods place an added strain on the bodys immune system, as it must work to eliminate toxins from the food. This takes vital energy away from the fight against the cancer.